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Genedata Inc curve fitting analysis
Curve Fitting Analysis, supplied by Genedata Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/curve+fitting+analysis/analysis+curve+fitting/us12653828-2598-14-11
Average 86 stars, based on 1 article reviews
curve fitting analysis - by Bioz Stars, 2026-09
86/100 stars

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Article Title: Discovery of a Series of Orally Bioavailable Androgen Receptor Degraders for the Treatment of Prostate Cancer.
Article Snippet: Androgen receptor (AR) signaling plays a key role in the progression of prostate cancer.. This study describes the discovery and optimization of a novel series of AR PROTAC degraders that recruit the Cereblon (CRBN) E3 ligase.. Having identified a series of AR ligands based on 4-(4-phenyl-1-piperidyl)-2-(trifluoromethyl)benzonitrile, our PROTAC optimization strategy focused on linker connectivity and CRBN ligand SAR to deliver potent degradation of AR in LNCaP cells.

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Article Snippet: On day 12 the plates containing DLD-1 BRCA2−/− cells and Cell Titre Glo 3D (Promega G9683) were equilibrated to room temperature, then 60 μL Cell Titre Glo 3D added per well and incubated on a shaking platform for 30 min. Plates were read on the Envision measuring luminescence for 1 second per well. .. The data was exported into a suitable software package (such as Genedata) to perform curve fitting analysis. ..



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